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While the purpose of melanin is protective, when produced in excess, it can form deposits in the skin that manifest as dark patches, isolated spots, or an overall darker facial appearance

McEwen ML, Sullivan PG, Rabchevsky AG, Springer JE (2011) Targeting mitochondrial function for the treatment of acute spinal cord injury

ROS-mediated inhibition of the proliferative signaling pathway The signaling pathways involving epidermal growth factor (EGF) and its receptor (EGFR) are essential for tumor development (Huang et al

Caffeine and caffeic acid, administered individually or in combination at doses of 5 and 25 mg/kg over 14 days, significantly decreased the activities of angiotensin converting enzyme (ACE) and arginase, while also lowering MDA levels and increasing NO levels
