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Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge

Potential Long-Term Risks Although AOD-9604 does not increase IGF-1 levels, there are concerns about its long-term metabolic effects, including: Unknown impact on fat metabolism regulation Since AOD-9604 alters fat-burning pathways, researchers are still investigating whether prolonged use could affect natural fat metabolism

Cell 117 , 495502 (2004)

Even if BPC-157 survives gastric acid, pepsin and pancreatic proteases remain active in the duodenum and small intestine at physiological pH and will hydrolyze unprotected peptide bonds