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However, it was also suggested that the association DOXGSH significantly decreased the antineoplastic effectiveness of DOX in a dose-dependent manner, thus proving a disadvantageous effect of GSH use [32]

Additionally, -tocopherol was shown to induce a cytostatic effect on the cell cycle (G0/G1 arrest) in C-6 glioma cells by suppressing extracellular signal-regulated protein kinase 1/2 and protein kinase C (PKC) upstream and retinoblastoma phosphorylation downstream, leading to the suppression of cyclin E and cyclin-dependent kinase (CDK) 2/4 and activation of p27 [99]

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