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This is significant because androgen-induced TGF-1 is a key mediator of hair follicle miniaturisation in androgenetic alopecia it signals follicular cells to stop growing

Ascenzi, P., Bocedi, A
Mlejnek, P

Accutane is the brand name for isotretinoin , a powerful prescription medication primarily used to treat severe nodular or cystic acne that hasnt responded to other treatments like antibiotics or topical medications
