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Curcumin supplementation may greatly increase the expression and transcriptional activity of Nrf2, therefore reducing AFB1-induced tissue damage in the liver, kidney, and ileum [69,70,71,79]

This is the first study to strongly suggest that HIF-1 phosphorylation at Thr645 might improve protein stability of HIF-1 via reducing UPS degradation under hypoxic conditions, thereby offering novel insights into modified phosphorylation and ubiquitination of HIF-1

MSCs can modulate immune responses by interacting with various immune cells, such as T cells, macrophages, and DCs

In this study, to increase the maleate production, three copies of the same gene involved in the production of 3HBA ( hyg5 ) were introduced into three different vectors, and two copies of the same gene involved in the production of gentisate ( 3hb6h ) were introduced into two different vectors