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The immune system is critical in wound healing with immune cells promoting wound healing by secreting immunomodulatory molecules mainly cytokines, chemokines, and growth factors, facilitating cellular crosstalk and guiding tissue repair besides tackling recurring infections culminating into chronic wounds

Surprisingly, the nucleotide-binding oligomerization domain protein 2 (NOD2) functions as a receptor for pattern recognition

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Physician-prescribed compounded topical formulations at therapeutic concentrations (2 to 10 percent or more) require a prescription from a licensed provider