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Active compounds from valerian appear to exert relaxing effects by interacting with GABA receptors
Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis
Besides, bypassing first-pass metabolism through non-oral routessuch as transdermal, sublingual, intranasal, or injectable formulationscan significantly improve systemic availability 30
bidirectional modulation of innate and adaptive immune responses (Si et al., 2025)
