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If you have high testosterone, your estradiol should be high. Treating that estradiol with an aromatase inhibitor may not be needed and can potentially crash your estradiol level

Alcohol can interfere with the absorption of vitamin B12, reducing the effectiveness of the treatment

It is known that reduction in CD38 expression on BM and circulating MM cells occurs rapidly after daratumumab initiation with significantly lower expression levels after the first infusion compared with baseline (potentially due to elimination of MM cells with high CD38 levels, endocytosis, or release in microvesicles), that may persist for at least 6 months after discontinuation [35]

Anaphylaxis is a severe reaction to a trigger, such as an allergy, and is potentially life threatening