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Excessive intracellular iron, as a powerful oxidant, can deteriorate DNA, RNA, proteins, and lipids, leading to oxidative damage [60, 61]

Cell 156 (1-2), 317331

Zou Y, Palte MJ, Deik AA, Li H, Eaton JK, Wang W, et al

While many biomolecules in RBCs have the potential to be oxidatively damaged, lipid oxidation has recently been shown to be particularly detrimental to RBC homeostasis [35]
