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In one report, clinicians observed that the initial response to melatonin had disappeared weeks after starting treatment, and that the favorable response returned with dose reduction [293]
Hemachandra Reddy, Texas Tech University Health Sciences Center, United States Reviewed by Bobby Thomas, Medical University of South Carolina, United States
Regulation of human osteoclast differentiation by thioredoxin binding protein-2 and redox-sensitive signaling
Thus, specific targeting of IGF-1R signaling post development may prove to be the best approach to achieve the benefits of low growth signals on healthspan and aging, without the potential unwanted side effects of combined adult-onset GH/IGF-1 deficiency
