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Techniques such as focused ultrasound-mediated BBB opening and local delivery strategies fall under this category, which is also referred to as the paracellular pathway [35,36]

Another study developed hollow mesoporous silica nanocarriers encapsulated with death-associated protein kinase 1 inhibitor TC-DAPK6 and rhodamine B, which were coated with macrophage membranes, enabling them to cross the BBB, selectively accumulating at inflammatory foci in epileptic lesions [116]

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doi: 10.1016/j.ab.2006.05.032