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Traditionally, it is recommended for conditions such as urinary tract discomfort, burning sensation during urination, frequent urination, and weakness related to the urinary and reproductive organs

ARDS is diagnosed using the Berlin criteria, i.e., acute onset or worsening within one week, bilateral lung infiltrates upon chest X-ray or computed tomography scan, origin exclusive of heart failure or volume overload, disease severity based on desaturation values (severe: arterial oxygen tension/inspired oxygen fraction (PaO 2 /FiO 2 ) 100 mmHg, moderate: PaO 2 /FiO 2 100 to 200 mmHg, and mild: PaO 2 /FiO 2 200 to 300 mmHg), and minimum positive end-expiratory pressure (PEEP) of 5 cm H 2 O for mechanical ventilation ( Figure 1 ) (Ranieri et al., 2012)

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Pharmacological sEH inhibition increases the EET/DHET ratio and reduces blood pressure in preclinical hypertension models, making this ratio a target engagement biomarker for sEH inhibitors in cardiovascular drug discovery