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Both loss and gain of functions have been proposed for mutant TDP-43 and mutant FUS, whereas gain of a toxic function is the preferred mechanism associated with mutant SOD1

Glutathione interferes with the activity of tyrosinase, an enzyme essential for melanin synthesis

It has been shown that approximately half of dietary l-threonine is extracted by the gut on the first pass, and used for synthesis of intestinal mucosal proteins, including mucins (Schaart et al 2005

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