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However, despite reduced CCT activity, PC levels remain unchanged due to a compensatory reduction in PC degradation, resulting in slower PC turnover that allows for greater remodeling of PC species enriched in polyunsaturated fatty acid (PUFA), which likely protects against endoplasmic reticulum stress and inflammation (71)

Alternatively, the PPARs and nhr-49 may have acquired their activities through convergent evolution

In peripheral white adipocytes, PTH and PTHrP stimulate lipolysis via PKA-mediated phosphorylation of HSL and PLIN1 and beiging via the upregulation of thermogenic genes including Ucp1, Dio2 , and Pgc1a (74, 210, 258, 275)
