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Strongest human evidence The METAOD006 (OPTIONS) Phase 2b trial randomized 502 adults with obesity (BMI 30-45 kg/m^2) to oral AOD-9604 (0.25, 0.5, or 1 mg/day) or placebo for 24 weeks alongside a supervised diet and exercise program

This makes it suitable for those who can't tolerate finasteride's side effects or prefer non-hormonal approaches

Sanofi (Europe and USA) designed SAR442257, a trispecific antibody where CD38 confers target specificity and CD3 and CD28 provide dual activation signals to optimize T lymphocyte effector functions and to ensure sustained proliferation