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combined icaritin with doxorubicin in a codelivery system to trigger potent immunogenic cell death, which further induced robust immunity and significantly repressed HCC progression [214]
Aside from antioxidant metabolism and regulation in response to elevated ROS, cells also recruit components of the DNA damage response (DDR) pathway to cope with the potential damaging effect of free radicals on DNA 29,43
References Dimitrievska M, Bansal D, Vitale M, Strouboulis J, Miccio A, Nicolaides KH, et al
Glycyrrhizin ameliorates insulin resistance, hyperglycemia, dyslipidemia and oxidative stress in fructose-induced metabolic syndrome-X in rat model
