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This non-stereoselectivity at the TLR4 receptor complex could potentially be leveraged for the enhancement of the therapeutic efficacy of opioids, including enhancing analgesic effects and reducing tolerance
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P2RX7 protein can be expressed but persists in the cytoplasm in an inactivated form (Benzaquen et al., 2019)
doi: 10.1111/j.1439-0396.2012.01284.x 31 HsiehC
