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Systemic Activation of NRF2 Alleviates Lethal Autoimmune Inflammation in Scurfy Mice
The compound was developed by Peter de Keizer and colleagues at Erasmus University Medical Center (Rotterdam) and published in a landmark 2017 Cell paper (Baar et al., Cell 169:132-147) demonstrating selective induction of apoptosis in cellular senescence research models
Among all the available markers of lipid peroxidation, F2-Isoprostanes is well suited as a biomarker for the following reasons: (i) In vivo formation of isoprostane increases as a function of lipid peroxidation
PMID 27983623
