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Following the invasion of surrounding tissues cancer cells can extravasate to the distant tissue parenchymas through the vascular system and form small nodules named micrometastases and further macroscopic tumors by colonization that secondary tissue (Hanahan and Weinberg 2011)

Immun Inflammation Dis

We previously showed that oral intake of long-term oscillating glucose (LOsG, 4 times/day for 38 days) can lead to -cells gaining metabolic memory in reactive oxygen species (ROS) stress, inhibition of insulin and SOD-2 expression, and the development of prediabetes with hypoinsulinemia and glucose intolerance [3]

[DOI] [PMC free article] [PubMed] [Google Scholar] 131.Lee K., Gudapati P., Dragovic S., Spencer C., Joyce S., Killeen N., Magnuson M.A., Boothby M