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Interestingly, rotenone prevented antimycin A to induce ROS production in complex I, but not in complex II [43]
Chung et al., 2013)
During this process, partial electron transfer via NADPH-CYP450 reductase to the CYP450-substrate complex results in "electron leakage", leading to the incomplete reduction of O to O 2 or HO [129]

While it is naturally found in the body, levels can be reduced by factors such as age, stress, and poor nutrition
