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Therefore, this review summarizes the most important and current findings of epigenetic contributions to autoimmune diseases in dermatology, including systemic lupus erythematosus (SLE), bullous skin diseases, psoriasis, and systemic sclerosis (SSc) (Fig.1)

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Several factors contribute to the acquisition by retinal microglia of a pro-inflammatory phenotype during ageing, including altered metabolism and reduced immunomodulatory signals from retinal neurons, such as the CX3CL1-CX3CR1 and CD200-CD200R signaling pathways, resulting in increased microglial activation (Chen et al., 2019)
