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cytosol) throughout the cell (Powers & Jackson, 2008)

TNF and IL-1 levels correlated directly with the VAS (r = + 0.45 and r = + 0.23, respectively) and HAQ (r = + 0.76 and r = + 0.48, respectively), inversely with the physical component of the SF-36 (r = -0.44 and r = -0.17, respectively)

Sarkar et al., 2022)

Fluctuations in SHBG concentrationsmodulated by metabolic status, insulin levels, and hepatic functioncan therefore influence the proportion of free E2 available for receptor activation, adding an additional regulatory layer to phase-dependent hormonal effects [28,29]
