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Epilepsy occurs in 55% of patients with the homozygous c.98-104del7ins3 mutation in the BTD gene, and for 38% of these patients, epilepsy is the initial symptom [73]

Current understanding is limited by simplified in vitro and short-term animal models and neglect of the periodontal pockets unique environment, which is characterized by fluid flow, protease activity, hypoxia, and low pH, all of which constrain local interventions

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