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Description
Compared to TTM, ATN-224 exhibited improved stability and a longer half-life, achieving a reduction in serum copper levels in 80% of patients within an average of 21 days (versus approximately 35 days for TTM)
A proof-of-concept study examined its impact in specific settings [citation:link3]
From these considerations, it should be appreciated that the critical molecule is succinyl-CoA, carrying the high-energy thioester bond that can be used to generate ATP by mtSLP
Cardiac energy metabolism in heart failure
