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It is curious that despite low cytoplasmic copper levels, CueO and PcoA exhibit a twin-arginine motif in their leader sequences, suggesting that they are translocated from the cytoplasm by the twin arginine translocation (Tat) pathway with copper-bound active sites (Huffman et al., 2002)

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J Nat Sci Res 2:153165 Farkhondeh T, Samarghandian S, Shaterzadeh Yazdi H, Samini F (2018) The protective effects of crocin in the management of neurodegenerative diseases: a review

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