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doi: 10.1016/j.redox.2025.103594 104 KobayashiSDDeLeoFR

It is worth emphasizing that although oxidative stress has been confirmed to play a role in many diseases, antioxidant supplements are not always good for the health (114) and sometimes may even cause harm (115117)

[9] Concomitant administration of large calcium supplements, thiazide diuretics, or aluminium-containing phosphate binders can potentiate vitamin D-mediated increases in serum calcium or phosphate, demanding periodic laboratory monitoring and dosage adjustments to avert nephrolithiasis or ectopic calcification

Think of this as an internal thermostat for cellular health