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However, adverse effects included fatigue, insomnia, and small increases in fasting glucose and insulin resistance
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The proteasomal ubiquitin receptors Rpn10 and Rpn1 were both postulated to bind the NUB1 UBL domain, and Rpn10 was also assumed to bind to the NUB1 UBA domains and the FAT10 UBL2 domain, suggesting some form of competing interactions or order of events that led to a confusing model for FAT10 recruitment 35,40,42
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