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SHMT2 also exerts influence on tumor cells ability to migrate and proliferate, supporting metabolic adaptations through Akt2 and n-Myc activation in human neuroblastoma cells [121], or hypoxia inducible factor 1 (HIF-1) activation in human gastric cancer cells [122]
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Wang F, Wang L, Wang Y, Li D, Hu T, Sun M, et al
TYRO3 induces anti-PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis
