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Upon exposure to sunlight, tretinoin rapidly degrades into less active or inactive metabolites , thereby reducing its therapeutic efficacy

[1] These structures, defined as chiral, have the peculiar characteristic of lacking second-order symmetry elements, namely a plane of symmetry, a center of inversion, or a rotation-reflection axis

Research has demonstrated that glutamate dehydrogenase (GLUD1) is expressed at a high level in lung adenocarcinoma cells, and lysine 503 (K503) has been identified as the primary ubiquitination site of GLUD1

The heightened serum AOPP and carbonyl levels may be indicative of the degree of oxidative stress, as oxidation affects the structure of proteins and increases their half-life