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Studies on mice models showed that a high-fat diet correlates with decreased GLP-1 production, reduced GLP-1 receptor sensitivity, impaired ghrelin secretion, and sensitivity, thus determining a diet-induced low-grade organ-specific and systemic inflammation [28]

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The MTHFR gene dictates how well you process folate and drive the methylation cycle, while the COMT gene controls how quickly you break down excitatory neurotransmitters like dopamine and adrenaline