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By targeting the ferroptosis-immune-metabolic axis with increasingly sophisticated and precise tools, we can envision a new era of personalized medicine for COPD

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Nevertheless, drawbacks of EDEA and BDEA, such as high hydrophobicity and low solubility, as well as the strong binding to serum albumin, need to be solved in future structural optimization to obtain better membrane permeability and solubility [204]

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