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Its ability to interact with multiple signaling systems allows for diverse experimental applications

People, who have had bariatric surgery procedures such as sleeve gastrectomy, Roux-en-y gastric bypass, duodenal switch, one anastomosis (mini) gastric bypass, single anastomosis duodenal ileal switch (SADIS), have reduced absorption of vitamin B12 and increased risk of developing vitamin B12 deficiency

Further studies are needed to confirm the lower B12 levels in relation to obesity or semaglutide use, and their effect when combined with GLP-1 drugs