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Glutathione is a ubiquitous protective compound in plants, but the structural and functional details of the proteins that synthesize it, as well as the potential biochemical mechanisms of their regulation, have only begun to be explored

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AKRs play a central role in the biosynthesis of androgens and estrogens, as well as in hormone-dependent malignancies

The process is often initiated at the periphery through sensitization of nociceptors but is critically cemented within the CNS via enduring synaptic potentiation and a loss of inhibitory control, a state known as central sensitization