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Clinical evaluation of recombinant human platelet-derived growth factor for the treatment of lower extremity ulcers

mPEGPLGA NPs showed an estimated size of 200 nm, which is small enough for pharmaceutical applications

Additionally, the study aimed to explore the methyl-dependent epigenetic mechanisms that play a role in regulating these biomarkers as well as investigate the potential of vitamin B12 in modulating the gene expression of these genes in leukocytes

Emphasize adequate hydration, monitor for signs of volume depletion, and check renal function at baseline, 4 weeks, 12 weeks, and any time side effects worsen