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However, the main regulator of pyroptosis is caspase 1, which is activated by the inflammasome, a large supramolecular complex

Brogi S, Ramunno A, Savi L, Chemi G, Alfano G, Pecorelli A, Brindisi M (2017) First dual AK/GSK-3 inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents

Treatment with an antagonist of the EP2 receptor (a downstream regulator of PTGS2) caused a significant reduction in the seizure frequency, incidence and duration of seizures, alluding to the role of PTGS2 46

[PMC free article] [PubMed] [Google Scholar] 171.Tsuji M., Yamamoto H., Sato T., Mizuha Y., Kawai Y., Taketani Y., Kato S., Terao J., Inakuma T., Takeda E