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Radical reaction of oxygen with PUFAs has been extensively reviewed by Gardner in 1989, 299 and the nature and formation mechanisms of nonenzymatic LA metabolites has been reviewed by Spiteller in 1998

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Loss of inositol 1, 4, 5-trisphosphate receptors from bile duct epithelia is a common event in cholestasis

John Myers , a Baltimore physician affiliated with Johns Hopkins, during the 1960s, and later refined by Dr
