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We used GO concentrations of 0, 2.5, 5, 10, and 50 mg/L, and applied stress treatments at three levels: without stress, salinity (80 mM NaCl), and alkalinity (40 mM NaHCO3)
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Notably, the BTK inhibitor and clinical compound ibrutinib showed additive effects with GPX4 inhibition, even at concentrations below its cytotoxic threshold, expanding its therapeutic relevance beyond BTK inhibition
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