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Being honest about that gap is not a weakness of this guide it is the accurate picture, and it is why every dosing figure here is framed as a research protocol rather than a recommendation

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16 Although NAM ranks as the most efficient substrate for NNMT, other heterocyclic compounds including thionicotinamide, 4-methylnicotinamide, isoquinoline, quinoline, and tetrahydroquinoline can also be effectively methylated by NNMT
