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The frequency of MTHFR homozygous genotype 677CC was 89% in the vitamin B-12 group and 85% in the placebo group ( P = 0.18), and the frequency of homozygous 677TT was 0.6% in both groups ( P = 1.00)

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Smoking is a potential risk factor for regular use of high-dose vitamin B12 supplements as hepatic tumorigenesis may be promoted

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