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By the same token, glial involvement is not necessarily inflammatory but may also alter CNS function via non-inflammatory mechanisms, e.g., neurovascular coupling (NVC) and thus blood flow distribution, modulating synaptic functions and thus neuronal connectivity and signaling, or even, especially in the case of oligodendrocyte involvement, by altering myelination

Your veterinarian may use blood tests and lab work to diagnose a B12 deficiency

From the evidence of Mao et al, interleukin-6, tumor necrosis factor-, and interleukin-1 in serum levels of DM-associated ED rats were increased, while interleukin-10 and interleukin-4 were decreased [85]