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Studies with NR supplementation in PD or HF patients have provided indications of impacting mitochondrial function in peripheral tissues, although evidence for impacting mitochondria in the primary target tissues was not reported 318,319

Dogs eating complete and balanced diets typically dont need B12 supplements unless diagnosed with a deficiency

Remission of clinical symptoms of deficiency associated with malabsorptive disorders requires a higher dose than treatment of dietary deficiency, and is less effective with increasing time between the onset of symptoms and the start of treatment