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If this mutation takes place in critical region of an oncogene or tumor suppressor gene, it can lead to cancer
During instances of microbial infection and cellular damage, the NLRP3 inflammasomea vital component of the innate immune systemmaintains regulation over caspase-1 activation and the secretion of pro-inflammatory cytokines such as IL-1/IL-18
Phytomedicine 23(2):114122 Zhao ZQ et al (2016b) Gefitinib induces lung cancer cell autophagy and apoptosis via blockade of the PI3K/AKT/mTOR pathway
Blum, W
