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Discovered DTP: Guided by the change of characteristics to explore formation of DTP cells It is challenging to investigate and delineate the formation mechanism of DTP cells owing to the absence of direct observation and recording

TLGST was potently inhibited with the cysteinyl protease inhibitors p -chloromercuribenzoic acid ( p CMB) and N-p-Tosyl-L-phenylalanine chloromethyl ketone (TPCK) which revealed its dependence on thiol reactivity and suggested it to have a cysteine protease activity

10.1093/eurheartj/ehae178 129 ModanwalS.MauryaA

Regarding oxidative stress regulation, exercise can activate the Nrf2/ARE pathway, upregulating Nrf2 expression to promote SOD activity and reduce oxidative stress markers like MDA, exerting a protective effect [68-70]