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In the bloodstream, acetylcarnitine concentrations are different in fed and fasted states, and accordingly acetylcarnitine availability is related to fatty acid load and metabolic rate, which is much higher in the fasted state
Thus, the human requirement for choline is especially influenced by the relationship between choline and other methyl group donors, such as folate and S-adenosylmethionine
Traumatic brain injury (TBI) is a major pediatric health problem with a rate of 500,000 per year in the US and leading to ~ 3000 pediatric deaths [134, 148]
