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doi: 10.1016/j.clinthera.2018.12.016 556 GoldenbergDLSimmsRWGeigerAKomaroffAL
Intriguingly, recent investigations have demonstrated that irisin upregulates the expression of TFAM (mitochondrial transcription factor A) through the activation of the SIRT1/PGC-1 signaling pathway, thereby enhancing mitochondrial metabolism and mitigating microglial activation 18
Systematic and state-of the science review of the role of environmental factors in amyotrophic lateral sclerosis (ALS) or Lou gehrig's disease
