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TB-500 exerts its primary effects through upregulation of actin, the cytoskeletal protein critical to cell structure and motility
Targeting PAJs disassembly not only prevents fibrosis from initiating but when given therapeutically resolves and reverses fully advanced fibrosis in chronic animal models
10.1016/j.cellsig.2012.02.010 39 HernandezP
They found that BMSCs and TSG-6 reduced MMP-3 and MMP-13 expression in IL-1-treated NPCs, thus restoring the expression of type II collagen and proteoglycan
