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Protein oxidation Cysteine residues in proteins are easily oxidized by ROS, reactive nitrogen species, reactive sulfur species, or GSH

24-OHC activates LXRs acting as transcription factor and regulating cholesterol biosynthesis (Radhakrishnan et al., 2007)

Pharmakokinetics and bioavailability study of ethacrynic acid as a modulator of drug resistance in patients with cancer

For instance, building upon the established role of GPX4 in suppressing ferroptosis in alveolar cells, the demonstrated therapeutic potential of mesenchymal stem cell-derived exosomes, the feasibility of CD44-mediated macrophage targeting, and the precedent for pulmonary nucleic acid delivery, the engineering of inhaled exosomes to deliver GPX4 mRNA specifically to alveolar macrophages represents a promising frontier (175, 178)