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Translational Considerations and Safety NNMT has emerged as a systems-level regulator linking methylation capacity, NAD biology, and adipocyte energetics
While AOD-9604 does not stimulate cell proliferation (no IGF-1 elevation), the precautionary principle applies for active malignancies
Other pathogenic factors, from the host and/or the bacteria, regulated by vitamin B12 or not, may also be important in the disease development and need to be investigated in future studies
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