diabetes glutathione in Oxidative Stress, Glutathione Insufficiency, and Inflammatory Pathways in Type 2 Diabetes Mellitus: Implications Diabetes and Low Cellular Glutathione

When the damage is minor or non-repetitive, wound healing is efficient, but when the injury is repetitive or the resolution is improper, components of the ECM continue to accumulate, leading to permanent scarring, disruption of tissue architecture, and organ dysfunction [8]

We found remarkably upregulated expression of the marker genes of inflammatory indicators ( TNF- , IL-6 , IL-1 , IL-23 , and Nfb1 ), chemokine CCL2 , and toll-like receptor 4 ( TLR4 , an important pathogen recognition receptor that recognizes mainly LPS of Gram-negative bacteria) in S-amlodipine-treated rats compared with control rats (Figure 2(gh))

Toxicol Lett 112113:357363

PMID 26810674