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Using the backward stepwise method, variables that resulted in the largest increase in the AIC were sequentially removed from the full model until the optimal AIC was achieved (Supplementary Table S2)
For example, tumors express irregular and tortuous vasculature, while ischemia is the lack of functional vessels, creating hypoxic environments and ultimately leading to tissue death

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[DOI] [PMC free article] [PubMed] [Google Scholar] (893).Wu Z
